Leptospirosis is a worldwide zoonotic disease caused by pathogenic Leptospira, which are classified into more than 250 serovars. Leptospirosis is most frequently recognized in dogs, swine, horses and rodents. However, the major carriers of the disease are rodents. Infections in humans often result from direct contact with the urine of infected animals or indirect contact with a urine-contaminated environment. The clinical manifestations may range from a mild flu-like illness to a severe and fatal disease.
Leptospira under dark-field microscope
J. Microbiol. Biotechnol. (2015), 25(4), 526–536
Cellular immune response in an in vitro restimulation assay